Childhood epilepsies beginning in the first few years of life are frequently characterized by seizures that are resistant to available treatments. A high seizure burden in early childhood likely contributes to the severe cognitive, behavioral, and motor delays common in these children. When indicated treatments fail to control their child's seizures, some parents turn to alternative treatments. Perhaps most desperate of all for new therapies have been parents of children with severe early life epilepsy. The data consist of anecdotal cases of children successfully treated with the medical marijuana, often cannabidiol-enriched preparations.